مطالعه تغییرات غلظت‌ هورمون‌های کورتیزول و تیروئیدی، و هم‌بستگی بین آن‌ها در طی دوره آبستنی، شیرواری و خشکی بز نژاد سانن

نوع مقاله: مقاله کامل

نویسندگان

گروه علوم درمانگاهی دانشکده دامپزشکی دانشگاه شهید باهنر‌کرمان، کرمان، ایران

چکیده

اهمیت هورمون‌های کورتیزول و تیروئیدی در روندهای متابولیسمی از دیرباز مورد تاکید قرار گرفته است. هدف از انجام این پژوهش، مطالعه تغییرات غلظت‌ هورمون‌های کورتیزول و تیروئیدی سرم، و هم‌بستگی بین آن‌ها در طی دوره آبستنی، شیرواری و خشکی در بز نژاد سانن است. برای انجام پژوهش حاضر از 20 راس بز ماده سه ساله (20/2±2/30 کیلوگرم) نژاد سانن با نمره وضعیت بدنی 5/3 (در زمان شروع آزمایش) استفاده شد. این دام‌ها در شرایط مدیریتی یکسان و برنامه تغذیه‌ای مشخص (متناسب با احتیاجات نگهداری و فیزیولوژیک هر دوره) نگهداری شدند. حیوانات در زمان‌های خشکی (دو ماه قبل از آبستنی)، 4 ماه آبستنی تک قلو (اتمام ماه چهارم)، یک ماه پس از زایش (دوره شیرواری) تحت مطالعه قرار گرفتند. غلظت سرمی هورمون کورتیزول روند افزایشی و هورمون‌های تیروئیدی روند کاهشی معنی‌داری در طی سه دوره مختلف مطالعه (از خشکی به آبستنی و از آبستنی به شیرواری) داشت (05/0>P). در دوره آبستنی، هم‌بستگی منفی معنی‌داری بین غلظت هورمون کورتیزول با تیروکسین (05/0>P و ضریب هم‌بستگی 44/0-) و غلظت هورمون کورتیزول با تری‌یدوتیرونین (01/0>P و ضریب هم‌بستگی 88/0-) دیده شد. اما غلظت هورمون کورتیزول در زمان شیرواری، با سطح سرمی هورمون‌‌های تیروئیدی هم‌بستگی نداشت. هر‌چند این تغییرات نمی‌تواند نشان‌دهنده وجود بیماری باشد اما مقادیر غلظت هورمون‌های کورتیزول و تیروئیدی ارائه شده، می‌تواند به‌عنوان شاخصی به‌منظور ارزیابی وضعیت متابولیک در شرایط مختلف فیزیولوژیک بز‌های نژاد شیری باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Changes of serum concentrations of cortisol and thyroid hormones and their correlation during pregnancy, lactation and dry periods in Saanen goats

نویسندگان [English]

  • A.S. Samimi
  • S.M. Aghamiri
Department of Clinical Sciences, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
چکیده [English]

The importance of serum concentrations of cortisol and thyroid hormones in metabolic process have been emphasized since old days. Aim of this study is to investigate the analysis of serum concentrations of cortisol and thyroid hormones and the correlation between them during lactation, pregnancy and dry periods in Saanen goats. A total of twenty female adult Saanen goats at age of 3 years with a body condition score of 3.5 (in the beginning of experiment) and average weight of 30.2±2.20 kg were selected. The animals were reared under the same management conditions and definite feeding program (according to their maintenance and physiologic demands). The whole duration of the study was divided into three periods including dry (non-pregnant) period, four-month single pregnancy (at the end of the fourth month) and lactating period. Serum concentrations of cortisol were increased and those of thyroid hormones were decreased significantly (p<0.05) during different periods (from dry period to pregnancy and pregnancy period to lactation). There was a significant negative correlation between serum concentrations of cortisol and thyroxin (T4) (p<0.05, r=-0.44) as well as between serum concentrations of cortisol and triiodothyronine (T3) (p<0.01, r=-0.88) in pregnancy period. There was no significant correlation between serum concentrations of cortisol and thyroid hormones during lactation period. These changes are not necessarily indicative of disease but may reflect the physiological status of animal. Serum concentrations of cortisol and thyroid hormones can be used as a marker to evaluate the metabolic status in various physiological conditions in dairy goats.

کلیدواژه‌ها [English]

  • Thyroid hormones
  • Cortisol
  • pregnancy
  • lactation
  • Saanen goat
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