مقایسه سه رژیم درمانی اندومتریت بالینی در گاوهای شیری در روزهای 21-33 پس از زایمان

نوع مقاله: مقاله کامل

نویسندگان

1 دانش آموخته دانشکده دامپزشکی دانشگاه فردوسی مشهد

2 دانشگاه فردوسی مشهد

چکیده

هدف از مطالعه حاضر مقایسه‌ی تأثیر درمان گاوهای شیری مبتلا به اندومتریت بالینی با سفتیوفور سدیم، کلوپرستنول و یا ترانکرون بین روزهای 21 تا 33 پس از زایمان بوده است. تعریف اندومتریت بالینی بر اساس حضور ترشحات چرکی/موکوسی چرکی، قطر گردن رحم بزرگ تر از 7.5 سانتی‌متر و وجود PMN به میزان ≥ 18% در نمونه‌های سیتولوژیک رحم بود. به این منظور، 80 رأس گاو شیری مبتلا به اندومتریت بالینی انتخاب و به طور تصادفی به چهار گروه مساوی تقسیم شدند. در گاوهای گروه اول سفتیوفور به میزان mg/kg 1 از وزن بدن بصورت IM به مدت 3 روز متوالی، گاوهای گروه دوم، دو دوز کلوپروستنول به فاصله 14 روز بصورت IM و گروه سوم 10 میلی گرم ترانکرون SC دو بار به فاصله 10 روز مورد استفاده قرار گرفت.  یک گروه هم بدون درمان به عنوان گروه شاهد در نظر گرفته شد. نمونه های سیتولوژیک از رحم با سایتوبراش از تمامی گاوها بار اول پیش از شروع درمان و بار دوم سه روز پس از آخرین تزریق اخذ شد. کاهش معنی داری در میزان PMN در گاوهای درمان شده در گروه‌های مختلف دیده شد، اما پاسخ به درمان با ترانکرون بهتر از درمان با سایر داروها بود (05/0 > p). در تمامی گروه ها از جمله در گاوهای شاهد قطر منفذ خارجی کاهش یافته بود لیکن این کاهش در ترانکرون بیشتر از سایر گروه ها بود (05/0 > p). نتیجه آن که درمان توسط ترانکرون و کلوپرستنول می تواند موجب بهبود علائم در آندومتریت بالینی گردد.

کلیدواژه‌ها


عنوان مقاله [English]

Comparison of three treatment protocols of clinical endometritis in dairy cows 21-33 days post-partum

نویسندگان [English]

  • S. Keshavarz 1
  • A. H. FallafRad 2
  • M. Heidarpour, 2
1 DVM graduated from Veterinary Faculty of Ferdowsi University.
2 Mashad Ferdousi University, Iran.
چکیده [English]

The objectives of this field trial was to compare the effects of clinical endometritis treament in dairy cows with either: Ceftiofur, Cloprostenol or Theranekron in 21-33 DIM. Clinical endometritis was defined as the presence of purulent/muco-purulent discharge and/or cervical diameter >7.5 cm and PMN concentration ≥18% in cytological samples. Eighty cows with clinical endometritis were assigned randomly into 4 groups. Group 1 cows received 3 consecutive doses of Ceftiofur (1 mg/kg IM; Excenel), in 3 days. Group 2 animals received 2 doses of Cloprostenol on days 1 and 14. Group 3 cows received two SC injections of Theranekron (10 mg/Cow) on days 1 and 10. Group 4 received no treatment. Inflammatory cells were collected by cytobrush. In order to dignose cows suffering from clinical endometritis, first cytobrush sample was taken before starting protocols and PMN cells were collecte, the second sample was taken 3 days after the last injection. All treatment protocols caused a favorable response, although response to Theranekron was more prominent than Ceftiofur (p<0.05). A decrease in PMN% was shown in group 2 and 3 in the samples (p<0.05), but not in group 1 animals (p>0.05). A decrease in the diameter of external os was found in all groups even in the control cows but it was more preminent in Teranekron group (p<0.05). Theranekron, caused improvements in clinical and cytological sings of endometritis (p<0.05). In conclusion in this study, systemic treatment of postpartum endometritis in cattle with Theranekron and PGF2α was effective to reduce inflammation.

کلیدواژه‌ها [English]

  • Dairy cow Postpartum Endometritis
  • Theranekron
  • Ceftiofur
  • cloprostenol
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