نوع مقاله : مقاله کامل
نویسندگان
1 گروه میکروبیولوژی و ایمنی شناسی، دانشکده دامپزشکی دانشگاه تهران، تهران، ایران
2 شرکت بهپرور، تهران، ایران
3 گروه میکروبیولوژی و ایمنی شناسی ،دانشکده دامپزشکی دانشگاه تهران ، تهران ، ایران
4 گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی، واحد علوم و تحقیقات، تهران، ایران
5 گروه میکروبیولوژی و ایمنی شناسی ، دانشکده دامپزشکی دانشگاه تهران ، تهران ، ایران
6 گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه آزاد کرج، البرز، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Introduction: Infectious bursal disease (IBD) is an acute and highly contagious disease that primarily affects young chickens presented by varying clinical symptoms. Among the available vaccines used to prevent disease outbreaks, live attenuated vaccines are considered as the most common. Aim and method: In this study, the effect of two vaccine types, a live attenuated vaccine, MyHatch UPM93, and a commercial immune complex vaccine, on immunization against IBD were compared whose effects on immune system suppression were also studied. Results: The results indicate that neither vaccine had negative effects on mortality rate. Studying the weight of the bursa of Fabricius (BF) relative to the body weight and bursa Fabricius histopathology in the group vaccinated with MyHatch showed less immune system suppression. Furthermore, MyHatch UPM93 vaccine performed better in generating specific antibodies against IBD, and non-interfering with immunization against Newcastle disease and Avian Influenza. Regarding the presence of the vaccinal virus in bursa Fabricius tissue, no virus genome was detected in the group vaccinated with Immunocomplex vaccine until the 14th day after the vaccination, unlike the group which was vaccinated with MyHatch UPM93 vaccine. On days 21 and 28 in both groups, an equal percentage of samples (80% and 100%, respectively) were positive, and on day 35, the MyHatch group had a lower percentage of positive samples compared to the immune complex group (60% versus 80%). Conclusion: It is hoped that in future researches, the effects of other vaccines, which are recently imported to Iran, on the immune system will be studied.
کلیدواژه‌ها [English]
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