نوع مقاله : مقاله کامل
نویسندگان
1 گروه علوم درمانگاهی دامپزشکی، واحد بابل، دانشگاه آزاد اسلامی، بابل، ایران
2 گروه انگل شناسی و قارچ شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران.
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Giardia lamblia is one of the most common intestinal parasites in Iran, which is treated with metronidazole. This drug has side effects and there are numerous reports of parasite resistance to this drug. Therefore, due to the importance of giardiasis and finding an alternative drug, the present study was conducted on the evaluation of the effect of the curcumin-loaded dendrimer nanoparticles on Giardia lamblia in vivo.
In this experimental study, after preparation of the nanodendrimer-curcumin, Size and chemical bonding between nanoparticles were determined by dynamic light scattering and Fourier-transform infrared technique, then the anti-giardial activity of synthesized nanoparticle was evaluated in infected mice by microscopic method. The final data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparisons test. Synthesized nanoparticles with an average size of 32 nm were suitable for drug delivery systems. The results showed that the highest effectiveness of synthesis nanoparticles in this study was observed at a dose of 16 mg/kg, with an efficacy of 79% in infected mice, which was statistically significant compared to the negative control group (P<0.05). Considering the better effect of the synthesized nano dendrimer-curcumin on Giardia lamblia in mice compared to metronidazole, it can be introduced as a new candidate for the treatment of giardiasis, however it requires further research.
کلیدواژه‌ها [English]
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