Comparison of the effecet of prosopis farcta extract and atorvastatin on blood metabolites and liver histology in hypercholesterolemic rats

Articles in Press

Document Type : Full Research Paper

Authors

1 Department of Animal Science, Faculty of Agriculture, Ilam University, Ilam, Iran

2 Department of Laboratory and Clinical Science, Faculty of Para Veterinary, Ilam University, Ilam, Iran

3 Department of Comparative Histology, Faculty of Para Veterinary Medicine, Ilam University, Iran

Abstract

Introduction: Cholesterol is one of the most important lipids in the body, which is essential for many vital biological pathways. Nevertheless, the disturbance in cholesterol homeostasis is associated with the occurrence of various metabolic diseases. Objectives: The aim of this study was conducted with of comparing the effect of the extract of the prosopis farcta and the drug atrostatin on blood parameters and histology of the liver in hypercholesterolemic rats. Methods: For this purpose, 24 male Wistar rats were prepared and randomly divided into 4 treatments with 6 replications: The experimental treatments included a control group with a basal diet, a hypercholesterolemia group with a high-fat diet (containing 2% cholesterol), a hypercholesterolemia group with 100 mg/kg of prosopis farcta extract by gavage, and a hypercholesterolemia group with 20 mg/kg/day of atorvastatin by gavage. At the end of the experiment, after blood collection, liver tissue and plasma samples were sent to the laboratory for measurement of blood parameters. Results: The results showed an increase in body weight as well as cholesterol, triglyceride, LDL, VLDL, glucose, malondialdehyde and plasma aspartate aminotransferase enzyme in the hypercholesterolemic group compared to the control group (p<0/05). Also, receiving a high-fat diet caused damage and severe tissue changes in the liver. However, treatment with prosopis farcta improved biochemical and histopathological changes. Conclusion: Therefore, prosopis farcta extract can be useful and effective in preventing or reducing the negative effects of hypercholesterolemia and dyslipidemia in people with obesity and fatty liver.

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Main Subjects

Veterinary Research & Biological Products

Articles in Press, Corrected Proof
Available Online from 19 May 2025

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History

  • Receive Date: 08 March 2025
  • Revise Date: 28 April 2025
  • Accept Date: 17 May 2025

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