Evaluation of administration of anesthetic drugs xylazine, diazepam and midazolam by intranasal method in Calandra Lark

Document Type : Short Communication

Authors

1 Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

2 DVM Graduated Student, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord-Iran.

3 دانشگاه شهرکرد

Abstract

It is important to use safe and effective sedation and anesthesia methods in birds for clini-cal and paraclinical examinations as well as surgeries. In routine surgeries, anesthesia drugs are mainly used intravenously or by inhalation. The purpose of this study is to com-pare the effect of administration of anesthesia drugs xylazine, diazepam and midazolam by intranasal method in the population of Calandra Larks. A total of 15 healthy adult Cal-andra Larks of both sexes weighing (140±20) grams were used in this study. Anesthetic drugs were administered intranasally, and then the time of unconsciousness, the duration of lying on the back and recovery from anesthesia were measured and recorded in each bird. According to the results, it was found that xylazine significantly reduces the duration of lying on the chest compared to midazolam and diazepam (17.1±9.3 seconds) and pro-vides faster anesthesia (P<0.005). ). However, no statistically significant difference was observed between midazolam and diazepam in this index. In terms of the duration of lying on the back (duration of anesthesia), xylazine significantly caused shorter anesthesia than midazolam and diazepam (38.5±13.8) and (P=0.0002). Also, regarding the length of time to return from anesthesia, diazepam with a longer duration showed a significant difference compared to the other two substances (306.7±101.9) and (P=0.0001). The present study showed that the intranasal administration of diazepam at a dose of 13 mg/kg can produce a long-term anesthesia and acceptable sedation along with a suitable recovery compared to the use of any of the above drugs alone.

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Main Subjects

Veterinary Research & Biological Products

Articles in Press, Accepted Manuscript
Available Online from 26 November 2023

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History

  • Receive Date: 08 October 2023
  • Revise Date: 15 November 2023
  • Accept Date: 25 November 2023

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