Evaluation of the possibility of Reversion of virulence and Safety tests of Razi Institute ‘s live attenuated Fowl Pox vaccine

Document Type : Full Research Paper

Authors

1 Department of Quality control, Razi Vaccine and Serum Research institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran

2 Department of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran

3 , Department of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran

4 Department of Poultry Disease Diagnosis, Razi Vaccine and Serum Research institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran

5 Department of Avian Diseases Research and Diagnostic, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran

Abstract

Vaccination is an important tool in controlling many diseases in the poultry industry. Today, a variety of vaccines, including live attenuated, killed and recombinant, etc. are produced against poultry pathogens. Despite the introduction of new generation vaccines, classical vaccines, including live attenuated vaccines, still retain their status and importance and are widely used. Vaccines containing the attenuated virus are prepared from mutant viruses whose antigenic properties are similar to those of the wild-type virus but are not able to cause all stages of pathogenicity in the host, including the problems and harms of such vaccines. The reversion to virulence in the vaccine may probably occur during viral replication in host. In this study, a reversion to virulence and safety tests was performed on Fowlpox vaccine seeds produced by Razi Institute. In order to perform the test vaccine seeds provided by the research and production of poultry vaccines, at least 5 consecutive passages of the virus were performed in SPF chickens and then the safety test of the vaccine was performed. The results of the tests showed that the vaccine virus produced by Razi Institute comply with BP and OIE specifications.

Keywords

References

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Veterinary Research & Biological Products
Volume 35, Issue 3 - Serial Number 3
September 2022
Pages 12-17

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History

  • Receive Date: 13 October 2021
  • Revise Date: 27 November 2021
  • Accept Date: 21 December 2021

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