The function of opioid receptors on hypophagia induced by ICV injection of Histamine in broiler chickens

Document Type : Full Research Paper

Authors

1 Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 epartment of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

3 Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

4 Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

5 Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Abstract

This study was aimed to investigate the function of opioidergic receptors on mediating the role histamine on central control of broiler feed intake. In this research, the role of mu, kappa and delta receptors of opioids on hypophagia induced by ICV injection of histamine was investigated in three separate experiments.In each experiment, 48 Ross 308 5-day broilers were randomly divided into 4 groups (12 birds per group) and the birds were given one of the four experimental treatments by ICV injection after 3 hours of feed deprivation. Experimental groups included of 1) normal saline (control), 2) 300 nmol histamine 3) 5 μg opioid receptor antagonist (mu receptor antagonist in the first experiment, kappa in the second experiment and delta in the third experiment) and 4) co-injection of histamine (300 nmol) and opioid receptor antagonist (5 μg). The cumulative intake of feed was measured after injection at 30, 60, and 120 minutes. Results showed that histamine injection in all three experiments reduced feed intake. Co-administration of the mu opioid receptor antagonist and histamine reduced the hypophagic effects of histamine and increased feed intake. However, histamine and kappa or delta receptor antagonists co-administered did not increase the intake of histamine-induced feed. Overall, the results of this study show that the mu opioid receptor mediates at least part of the histamine-induced hypophagic effect in broilers, while kappa and delta opioid receptors have no significant effect.

Keywords

References

1- Alimohammadi, S., M. Zendehdel and V. Babapour. 2015. Modulation of opioid-induced feeding behavior by endogenous nitric oxide in neonatal layer-type chicks. Veterinary research communications 39: 105-113.
2- Bodnar, R. J. 2016. Endogenous opiates and behavior: 2014. Peptides 75: 18-70.
3- Bungo, T., K.-I. Dodo, K. Kawamura, T. Izumi and H. Ueda. 2005. Effects of various μ-and δ-opioid ligands on food intake in the meat-type chick. Physiology & behavior 85: 519-523.
4- Bungo, T., K. Kawamura, T. Izumi, K.-I. Dodo and H. Ueda. 2004. Feeding responses to μ-, δ-and κ-opioid receptor agonists in the meat-type chick. Pharmacology Biochemistry and Behavior 78: 707-710.
5- Davis, J. L., D. T. Masuoka, L. K. Gerbrandt and A. Cherkin. 1979. Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiology & Behavior 22: 693-695.
6- Dodo, K.-I., T. Izumi, H. Ueda and T. Bungo. 2005. Response of neuropeptide Y-induced feeding to μ-, δ-and κ-opioid receptor antagonists in the neonatal chick. Neuroscience letters 373: 85-88.
7- Eidi, M., S. Oryan, A. Eidi and L. Sepehrara. 2003. Effect of morphine, naloxone and histamine system on water intake in adult male rats. European journal of pharmacology 478: 105-110.
8- Gądek-Michalska, A. and J. Bugajski. 1988. Naloxone antagonizes a central histaminergic stimulation of corticosterone secretion in rats. Agents and actions 23: 254-256.
9- Ganci, F., A. Sacconi, V. Manciocco, I. Sperduti, P. Battaglia, R. Covello, P. Muti, S. Strano, G. Spriano and G. Fontemaggi. 2016. MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma. Head & neck 38.
10- Jaefari-Anari, M., M. Zendehdel, H. Gilanpour, A. Asghari and V. Babapour. 2018. Central Opioidergic System Interplay with Histamine on Food Intake in Neonatal Chicks: Role of µ-Opioid and H1/H3 Receptors. Brazilian Journal of Poultry Science 20: 595-604.
11- Kaneko, K., M. Yoshikawa and K. Ohinata. 2012. Novel orexigenic pathway prostaglandin D2–NPY system–Involvement in orally active orexigenic δ opioid peptide. Neuropeptides 46: 353-357.
12- Khalilzadeh, E., F. Azarpey and R. Hazrati. 2017. The effect of histamine h1 receptor antagonists on the morphine-induced antinociception in the acute trigeminal model of nociception in rats. Asian J Pharm Clin Res 10: 1-5.
13- Khan, M. S. I., T. Ohkubo, N. Masuda, T. Tachibana and H. Ueda. 2009. Central administration of metastin increases food intake through opioid neurons in chicks. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 153: 209-212.
14- Młynarska, M. 1990. Antagonistic effect of naloxone on the hypertensive response of intraventricularly administered histamine. Agents and actions 30: 226-230.
15- Mobarakeh, J. I., K. Takahashi, S. Sakurada, A. Kuramasu and K. Yanai. 2006. Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. Neuropharmacology 51: 612-622.
16- Mobarakeh, J. I., K. Takahashi and K. Yanai. 2009. Enhanced morphine-induced antinociception in histamine H3 receptor gene knockout mice. Neuropharmacology 57: 409-414.
17- Ohinata, K., K. Takagi, K. Biyajima, Y. Fujiwara, S. Fukumoto, N. Eguchi, Y. Urade, A. Asakawa, M. Fujimiya and A. Inui. 2008. Central prostaglandin D 2 stimulates food intake via the neuropeptide Y system in mice. FEBS letters 582: 679-684.
18- Olanrewaju, H., J. Thaxton, W. Dozier, J. Purswell, W. Roush and S. Branton. 2006. A review of lighting programs for broiler production. International journal of poultry science 5: 301-308.
19- Samarghandian, S., H. Ohata, N. Yamauchi and T. Shibasaki. 2003. Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats. Neuroscience 116: 519-524.
20- Shiraishi, J.-i., K. Yanagita, M. Fujita and T. Bungo. 2008. μ-Opioid receptor agonist diminishes POMC gene expression and anorexia by central insulin in neonatal chicks. Neuroscience letters 439: 227-229.
21- Suzuki, T., K. Takamori, Y. Takahashi, M. Narita, M. Misawa and K. Onodera. 1994. The differential effects of histamine receptor antagonists on morphine-and U-50,488 H-induced antinociception in the mouse. Life sciences 54: 203-211.
22- Taati, M., V. Babapour, A. Kheradmand and M. Tarrahi. 2009. The role of central endogenous histamine and H1, H2 and H3 receptors on food intake in broiler chickens. Iranian Journal of Veterinary Research 10: 54-60.
23- Trescot, A. M., S. Datta, M. Lee and H. Hansen. 2008. Opioid pharmacology. Pain physician 11: S133-153.
24- Turner, T. T. and J. J. Lysiak. 2008. Oxidative stress: a common factor in testicular dysfunction. Journal of andrology 29: 488-498.
25- Zendehdel, M., S. Hassanpour, V. Babapour, S. Charkhkar and M. Mahdavi. 2015. Interaction between endocannabinoid and opioidergic systems regulates food intake in neonatal chicken. International Journal of Peptide Research and Therapeutics 21: 289-297.
26- Zheng, H., L. M. Patterson and H.-R. Berthoud. 2007. Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. The Journal of Neuroscience 27: 11075-11082.
 
Veterinary Research & Biological Products
Volume 34, Issue 1
March 2021
Pages 94-101

Files

History

  • Receive Date: 12 December 2019
  • Revise Date: 03 February 2020
  • Accept Date: 04 February 2020

Share

How to cite

Statistics