Investigating The Role of NPY Receptors on Water Intake in Neonatal Broiler Chicken

Document Type : Full Research Paper

Authors

1 Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

2 Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Abstract

Imbalance of body fluids can cause numerous problems and diseases including ascites in poultry. Therefore, identifying the mechanisms involved in controlling water intake can help to better understand the pathophysiology of related diseases. NPY is one of the neuropeptides involved in central control of water intake. When deprived of water, the mRNA synthesis of this neuropeptide increases in the hypothalamus. So, this study examines the role of NPY1 and NPY2 receptors in central control of water intake. Two series of experiments were conducted in this study. In the first and second experiments, male broiler chickens respectively received 10 μl of Evans Blue, 20 μg, 10 μg, 5 μg and 2.5 μg of B5063 and SF22 (receptors antagonists NPY) by ICV injection. Then cumulative water intake was measured at 90 and 180 minutes after injection. The results showed that ICV injection of B5063 (20, 10, 5 and 2.5 μg) resulted in reduction in water intake compared with the control group (p < 0.05), while none of the SF22 doses had an effect on cumulative water intake compared to the control group (P>0.05). The results of these experiments showed that the effect of NPY on water intake may be conducted through NPY1 receptor.

Keywords

References

1- Ahmadipour, B. 2018. The inhibition of Securigera securidaca herb on the incidence of pulmonary hypertension in broiler chickens reared at high altitude. VRBP. 121: 34-42.
2- Ando, R., Kawakami, S.I., Bungo, T., Ohgushi, A., Takagi, T., Denbow, D.M., Furuse, M. 2001. Feeding responses to several neuropeptide Y receptor agonists in the neonatal chick. Eur J Pharmacol. 427(1):53-59.
3- Bi, S., Kim, Y.J., Zheng, F. 2012. Dorsomedial hypothalamic NPY and energy balance control. Neuropeptides. 46(6): 309-314.
4- Braun, E. 2015. Osmoregulatory systems of birds. pp. 469-485, In: Scanes, C., (ed.), Sturkie's Avian Physiology. Sixth edition. Academic Press, Ireland.
5- Bromée, T., Sjödin, P., Fredriksson, R., Boswell, T., Larsson, T.A., Salaneck, E., Zoorob, R., Mohell, N., Larhammar, D. 2006. Neuropeptide Y-family receptors Y6 and Y7 in chicken. FEBS J. 273(9): 2048-2063.
6- Capuano, C.A., Leibowitz, S.F., Barr, G.A. 1993. Effect of paraventricular injection of neuropeptide Y on milk and water intake of preweanling rats. Neuropeptides. 24(3):177-182.
7- Carew, L.B., Evarts, K.G., Alster, F.A. 1998. Growth, feed intake, and plasma thyroid hormone levels in chicks fed dietary excesses of essential amino acids. Poult Sci. 77(2): 295-298.
8- Hashimoto, H., Fujihara, H., Kawasaki, M., Saito, T., Shibata, M., Otsubo, H., Takei, Y., Ueta, Y. 2007. Centrally and Peripherally administered ghrelin potently inhibits water intake in rats. Endocrinology. 148 (4):1638- 1647.
9- Jafarzadeh, S.h., VahdatPour, T., Ebrahimnejad, Y. 2017. The effects of Terazosin on electrocardiography, cardiac indexes and performance in broiler chickens fed dense diet to induce ascites.VRBP. 118: 108-119.
10- Jamalpour, M., Dadpasand, M., Atashi, H., Niazi, A., Kharrati, K.H., Hashemi, S.M. 2018. Bioinformatics and phylogenetic analysis for 5′ UTR region of neuropeptide Y gene and its association with body weight and egg production traits in Fars native chickens. JIAS. 49(3): 453-458.
11- Jonaidi, H., Noori, Z. 2012. Neuropeptide Y-induced feeding is dependent on GABAA receptors in neonatal chicks. J Comp Physiol A. 198 (11) 827-832.
12- Kameda, Y., Miura, M., Nishimaki, T. 2001. Localization of neuropeptide Y mRNA and peptide in the chicken hypothalamus and their alterations after food deprivation, dehydration, and castration. J Comp Neurol. 436(3):376-388.
13- Kanatani, A., Mashiko, S., Murai, N., Sugimoto, N., Ito, J., Fukuroda, T., Fukami, T., Morin, N., MacNeil, D.J., Van der Ploeg, L.H., Saga, Y. 2000. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. 141(3): 1011-1016.
14- Kuo, A.Y., Cline, M.A., Werner, E., Siegel, P.B., Denbow, D.M. 2005. Leptin effects on food and water intake in lines of chickens selected for high or low body weight. Physiol Behav. 84 (3): 459-464.
15- Levens, N.R., Félétou, M., Galizzi, J.P., Fauchere, J.L., Della-Zuana, O., LonchamPt, M. 2004. Neuropeptide Y and Related Peptides. Springer Berlin Heidelberg, Berlin.
16-Lundell, I., Boswell, T., Larhammar, D. 2002. Chicken neuropeptide Y-family receptor Y4: a receptor with equal affinity for pancreatic polypeptide, neuropeptide Y and peptide YY. J Mol Endocrinol. 1(28):225.
17-- Singh, P.K., Shekhar, P., Kumar, K. 2011. Nutritional and managemental control of ascites syndrome in poultry. Int J Livest Prod. 2 (8) 117-123.
18- Williams, C.L., Tabler, G.T., Watkins, S.E. 2013. Comparison of broiler flock daily water consumption and water-tofeed ratios for flocks grown in 1991, 2000–2001, and 2010–2011. J Appl Poult Res. 22 (4) 934-941.
19- Yousefi, A.R., Shojaei, M., Zendehdel, M. 2018. Evaluation the role of central serotonin and 5HT2c serotonin receptor on feed intake in female layer-type Bovans chicken by intracerebroventricular (ICV) injection of Para-chlorophenylalanine and SB242084. VRBP.122: 55-62.
20- Yousefvand, S., Hamidi, F., Zendehdel, M., Parham, A. 2017. Effects of insulin and somatostatin on water intake in neonatal chickens. Iran J pp. 2(3): 166-173.
21- Yousefvand, S., Hamidi, F., Zendehdel, M., Parham, A. 2018a. Hypophagic effects of insulin is mediated via NPY1/NPY2 receptors in broiler cockerels. Can J Physiol Pharmacol. 96(12):1301–1307.
22- Yousefvand, S., Hamidi, F., Zendehdel, M., Parham, A. 2019. Interaction of neuropeptide Y receptors (NPY1, NPY2 and NPY5) with somatostatin on somatostatin-induced feeding behaviour in neonatal chicken. Br Poult Sci. 60(1):71-78.
Veterinary Research & Biological Products
Volume 33, Issue 3
September 2020
Pages 101-107

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History

  • Receive Date: 29 June 2019
  • Revise Date: 28 August 2019
  • Accept Date: 28 August 2019

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