Effects of levothyroxine and propylthiouracil intake on thyroid hormones, blood parameters and physical performances of Japanese quails ٪

Document Type : Full Research Paper

Authors

Faculty of Animal and Veterinary Sciences, Shabestar Branch, Islamic Azad University, Shabestar, Iran

Abstract

The aim of this experiment was to investigate the effects of two common thyroid gland medications i.e. levothyroxine and propylthiouracil on physical performance, hormones and blood parameters of Japanese quails. The experiment was conducted using a completely randomized design including 144 Japanese quail chicks that were randomly distributed in 3 different groups 4 replicates for each, while each replicate included 12 quails. Our comparative experiments control group (no drug), levothyroxine treatment and propylthiouracil treatment. The performance parameters were recorded and compared at 21 and 35 days. The blood samples were drawn at the end of the experiments period for specific hormones analysis using ELISA technique and blood parameters assessments using a biochemical auto-analyzer system. The results showed that at 21 days of age, feed conversion ratio and feed intake of propylthiouracil decreased (p<0.05). Also, the weight of the thighs at the age of 35 days in quails treated with propylthiouracil, was significant higher (p<0.05). In our experimental treatments, other analyzed data i.e. blood parameters and thyroid hormones showed no significant modifications (p>0.05).According to our results, it was found that the drugs used for the regulation of the thyroid gland activity in man, have no significant effects on Japanese quails. It can be concluded that this species is resistant to these chemical agents and levels of levothyroxine and propylthiouracil commonly prescribed for human consumption have very low effects on secreting, cells of quail thyroid glands. However, there is a necessity to determine the physiological reasons for this resistance.

Keywords

References

1. Arslan, M. 2002. The effects of hyperthyroidism and hypothyroidism on body weight and carcass values in Japanese quails (Coturnix coturnix japonica) J. Fac. Vet. Med. Univ. Istanbul, 28(1), 73-79.
2. Chauhan, R. 2003. The Effects of Hyperthyroidism and Hypothyroidism on Body Weight and Carcass Values in Japanese Quails (Coturnix Coturnix Japonica). Veterinary laboratory diagnosis. International Book Distributing Company. Lucknow, U.P.104-106.
3. Closter, A., P. Van, J.Van, H. Bovenhuis, and M. Groenen. 2009. Genetic and phenotypic relationships between blood gas parameters and ascities-related traits in broilers. Poultry Science. 88: 483-490.
4. Collin, A., J. Buyse, P. van, V. Darras, R. Malheiros, V. Moraes, G. Reyns, M. Taouis, and E. Decuypere. 2003. Cold-induced enhancement of avian uncoupling protein expression, heat production and triiodothyronine concentrations in broiler chicks. General and Comparative Endocrinology. 130(1): 70-77.
5. Decuypere, E., J. Buyse, C. Scanes, I. Huybrechts, and E. Kuhn.1987. Effects of hyper or hypothyroid status on growth, adiposity and levels of growth hormone, somatomedin C and thyroid metabolism in broiler chickens. Reproduction Nutrition Developpement. 27: 555-565.
6. Donatelli, M., P. Assennto, V. Abbadi, L. Bucaolo, V. Compagno, and S. Vecchio. 2003. Cardiac changes in subclinical and overt hyperthyroid women: retrospective study. International Journal of Cardiology.90: 159-164.
7. Drews, R. 2003. Critical issues in hematology: anemia, thrombocytopenia, coagulopathy, and blood product transfusions in critically ill patients. Clinics in Chest Medicine. 24(4):607–625.
8. Fleszeghy, k., G. Baghdy and C. Nyakas. 2000. Blunted pituitary adrenocortical stress response in adult rats’ fllowing neonatal dexamethasone treatment. Journal of Neuroendocrinology. 12: 1014- 1021.
9. Gayton. 2003. Medical Physiology. Saunders. 858-868.
10. Green, W. 1996. Antithyroid compounds. Philadelphia clinical text. 266- 276.
11. Hassanzadeh, M., M. Bozorgmerifar, A. Akbari, J. Buyse, and E. Decuypere. 2000. Effect of intermittent lighting schedules during the natural scoot period on T3-induced ascites in broiler chickens. Avian Pathology. 29: 433-439.
12. Hej, H., A. Ohtsuka, and K. Hayashi. 2000. Selenium influences growth via thyroid hormone status in broiler chickens. British Journal of Nutrition. 84: 727-732.
13. Howarth, B., & Marks, H. L. (1973). Poultry science, 52(1), 326-331.
14. Kamienski. B, and J. Keog. 2006. Pharmacology demystified. McGrew-Hill Companies, Inc. 196, 283, 421 and 414.
15. Katzung, B. 2006. Basic pharmacology. New York, Williams. 720-729.
16. Katovich, M., and C. Barney. 1983. Alteration of peripheral beta-adrenergic responsiveness in fasted rats. Life Sciences. 33(14): 1383-1393.
17. Leung, P. and B. March. 1985. The thyroidal response to chronic goitrogenic stimulation and the persistence of effects of early goitrogenic stimulation. Canadian Journal of Physiology and Pharmacology. 54: 583-589.
18. Luger, D., D. Shinder, V. Rzepakovsky, M. Rusal, and S. Yahav. 2001. Association between weight gain, blood parameters and thyroid hormones and the development of ascites syndrome in broiler chickens. Poultry Science. 80: 965-971.
19. Nazifi, S, M. Mehrdad, and R. Mohammady. 1997. Survey of serum protein electrophoresis by native poultry. Tehran Faculty of Veterinary Medicine. 1: 42- 29, 176- 175 and 188. (InPersian)
20. NRC. 1994. Nutrient requirements of poultry, 9th rev. edn (Washington. DC, national Academy press).
21. Panahi dehghan, M., S. Rasoulnajhad, M. Kermani, M. Modirsanei, M. Mahmoodabady, S. Mirsalimi, and F. Niknafs. 1995. Poultry physiology. Sazmane eghtesady cosar. (In Persian)
22. Raieesy, M,. A. Zareh shahnea, M. Irani, and A. Roofchaiee. 2010. Study of hypothyroidism and hyperthyroidism on performance of growth in broiler chickens. Conference on new ideas in agriculture. (In Persian)
23. Raeesi, M., Roofchaee, A., Shahneh, A. Z., & Zanousi, M. B. P. (2012). Effects of transient hypo-and hyper-thyroidism on growth performance, organ weights and serum levels of thyroid hormones in broiler chickens. African Journal of Biotechnology, 11(6), 1529-1534.
24. Rosebrough, R., B. Russell, and M. Richards. 2007. Responses of chickens subjected to thyroid hormone depletion-repletion. Comparative Biochemistry and Physiology. 147: 543-549.
25. Safarzadeh, H. 2004. Survey of Compensatory growth in fattening lambs Atabay (Dalagh). Colleges of Agricultural Sciences and Natural Resources, Gorgan University of Agricultural Sciences. (InPersian)
26. SAS. (2001). Institute, SAS user’s Guide: Statistics Version 9.1.3. SAS Institute Inc, Cary, NC.
27. Singh, A., E. Reineke, and K. Ringer. 1967. Thyroxine and triiodothyronine turnover in the chicken and the bob white and thejapanes quail. Proc second symposium. London: William Heineman.
28. Vahdatpour, T, and S. Sandougchian. 2011. Poultry hematology. Parivar publication. (InPersian)
29. Whistett, J., J. Pollinger, and S. Matz. 1982. Adrenergic receptors and catecholamine sensitive adenylate cyclase in developing rat ventricular myocardium; effects of thyroid status. Pediatric research. 16(6): 463-469.
30. Yousefvand, N., M. Shirzadi. F. Yavary, S. Dezfoulinejhad, and R. Kaboudi. 2010. The effect of propylthiouracil induced hypothyroidism on serum levels of zinc and copper in rats. 908-900. (In Persian).
Veterinary Research & Biological Products
Volume 30, Issue 2
May 2017
Pages 76-88

Files

History

  • Receive Date: 14 July 2016
  • Revise Date: 12 August 2016
  • Accept Date: 20 August 2016

Share

How to cite

Statistics