Effect of levamisole on cholesterol, triglycerol and lipoprotein level of common carp (Cyprinus carpio L.) blood serum

Editorial

Authors

1 Professor, Clinical Sciences Department, Veterinary Faculty, Shahid Chamran University of Ahvaz, Ahvaz-Iran

2 Associate Professor, Clinical Sciences Department, Veterinary Faculty, Shahid Chamran University of Ahvaz, Ahvaz-Iran,

3 Graduated Student – Veterinary Faculty- Shahid Chamran University. Ahvaz-Iran

Abstract

Levamisole is one of the anti-parasitic drugs that widely used in veterinary and aquatic animal medicine. Previous investigation showed that levamisole has some stimulatory effect on immunity and liver metabolism. In this investigation effect of levamisole on cholesterol, triglycerol and lipoproteins as metabolic activity indicator has been studied. For this purpose 120 common carp randomly divided to 4 groups. Three groups were fed with food contain three levamisole concentrations (100, 500, 1000 mg/kg levamisole). The 30 other fish were fed with same food but without levamisole. After 30 days blood were collected and cholesterol triglycerol level and lipoproteins were measured. Result showed that in Triglyceride level in 500 and 1000 mg/kg group was significantly higher than the 100 mg/kg and the control group (p<0.05). But the cholesterol levels in experimental groups were significantly lower than the control. High-density lipoproteins (HDL) level was decreased in all experimental groups in comparison with the control group (p<0.05). However, the low-density lipoproteins (LDL) and the very-low-density lipoproteins (VLDL) levels were increased in all experimental groups in comparison with the control (p<0.05). This investigation showed that levamisole had mark effect on cholesterol and triglycerol level of serum in common carps, however the changes were laid in approximate levels of normal ranges for the particular factor.

References

 
1-Alvarez-pellitero p. Stija – Bobadilla, A. and Bermuolez, R. and Quiroga, M.I. (2006) Levamisole activates several innate immune factors in Scophthalmus moximus (1) (Teleostei) International Journal of Immunopathology and Pharmacology. 19, 4, 727-738.
2-Alvaro, D., Benedetti, A., Marucci, L., Monache, M., Monterubbianesi, R., Di Cosimo, E., Perego, L., Macarri, G., Glaser, S., Sage, G., Alpini, G. (2003) The function of alkaline phosphatase in the liver: Regulation of intrahepatic biliary epithelium secretory activities in the rat. Hepatology. 32. 2, 174 – 184.
3- Baba, T., Watase, Y; Yoshinage, Y. (1993) Activation of mononuclear phagocyte function by levamisole immersion in carp. Nippon Suisan Gakkaishi, 59, 301-307.
4- Baruah, N.D, Prasad. K.P., (2001) Efficacy of levamisole as immunostimulant in macrobrachium rosenbergii (de man). Journal of Aquaculture in the Tropics, 16 (2), 149-158.
5-Cuesta, A., Meseguer, J., Esteban, M.A., (2004.) Total serum immunoglobulin M are affected by immunomodulators in sea bream (Sparus aurata L.). Veterinary Immunology and Immunopathology. 101, 203–210.
6- Engelmann, G.L. and Richardson, A.G. (1986) Effects of levamisole on primary cultures of adult rat hepatocytes. Biochemical Pharmacology. 35. 1. 1547-1554.
7- Ispir, U. and Dorueu, M. (2005) A study on the effects of levamisole on the immune system of Rainbow trout (Oncorhynchus mykiss, walbaum). Turkish Journal of veterinary animal sciences -29: 1169-1176.
8- Kumar, J. and Sahoo, P.K. (2005) Non-specific immune response of healthy Clarias batrachus to several immuno stimulants. Aquaculture. 12. 1-12.
9- Li, P.,Wang, X., Gatlin III, D.M. (2004) Excessive dietary levamisole suppresses growth performance of hybrid striped bass (Morone chrysops × M. saxatilis), and elevated levamisole in vitro impairs macrophage function. Aquacic Research. 35, 1380–1383.
10- Metaye, T., Mettey, Y. Lehuede, J., Vierfond, J.M. and Lalegerie, P. (1988) Comparative inhibition of human alkaline phosphatase and diamine oxidase by bromo-levamisole, cimetidine and various derivatives. Biochemical pharmacology. 37, 22, 4263-4268.
11- Mulero, v., Esteban, M.A. Munoz, J., Meseguer, J., (1998) Dietary intake of levamisole enhances the immune response and disease resistance of the marine teleost gilthead seabream (Sparus aurata L.). Fish and Shellfish Immunology. 8: 49-62.
12- Nazifi, S. Gheisari, H.R. and Shaker, F. (2002) Serum lipid and lipoprotein and their correlations with Thyroid hormones in clinically healthy goat. Veterinarski  Archieves. 12 (5): 249-257.
13- Nazifi, S., Saed, M and Abedi, M. (2003) Serum lipid profiles and their correlation with thyroid hormones in clinically healthy Turkman horses .J Clinical Pathology, 12: 42-55.
14- Nazifi, S., Saed, M. and Ghvami, M. (2002) Serum lipid profile in Iranian fat-tailed sheep in late pregnancy and parturation and during the post parturation Journal of Veterinary Medical Association 49: 9-12.
15- Pancarci, S. M, Gungor, O., Gurbulak, K., Cenesiz, M., Kaya, M., Cenesiz, S. and Guzeloglu, A. (2007.) Effects of levamisole on pregnancy in ewes. Bulletin of Veterinary Institute Pulawy. 51, 253-256.
16- Peng- Li, X.W. and Delbert, M.G. (2006.) Evaluation of levamisole as a feed additive for growth and health management of hybrid striped bass (Morone Chrysops × Morone Sacxatilis). Aquaculture, 251: 201-209.
17- Qiao, Yanliang, Yang, Hanchun, Guo, Yupu, et al. (2000.) In vivo effects of levamisole on cellular and hormonal immunity in Chicks. Animal Husbandry and Veterinary Medicine. 32 (2), 1-4.
18- Siwichi A.K. and Korwin-Kossakowski, M. (1988.) The influence of levamisole on the growth of carp (Cyprinus carpio L.) larvae. Journal of Applied Ichthyology. 4: 178-181.
19- Thomaskutty, K.G., Basi, N.S., Mckenzie, M.L. and Pointer, R.H. (1993.) Regulation of pyruvate dehydrogenase activity in rat fat pads and isolated hepatocytes by levamisole. Pharmacological Research. 27. 3. 263-272.
20- Umbreit, J.N., Conrad, M.E. (1999.) Method of inhibiting Cholesterol transport. United States Patent. 5, 872, 141.
21- Zilberg, D., Findlay, V.L., Girling, P., Munday, B.L., (2000.) Effects of treatment with levamisole and glucans on mortality rates in Atlantic salmon, Salmo salar L. suffering from amoebic gill disease. Bulletin of European Association of Fish Pathologists. 20, 23–27.
 

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History

  • Receive Date: 19 April 2015
  • Accept Date: 19 April 2015

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